![]() ![]() Recent year to the earliest year), and alphabetically by first author within aĪnalysis of polycerate mutants reveals the evolutionary co-option of HOXD1 for horn patterning in bovidae. Goats and sheep are herded on grasslands at an altitude of 4,3005,000 m, the same. Note: the references are listed in reverse chronological order (from the most These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table. Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers. Click it again to sort in a descending order. Readers can re-sort on any column by clicking on the column header. Genotyping of this variant in 77 case and 355 control goats originating from 24 distinct populations revealed a 100 percent association between polyceraty and heterozygosity for the large insertion-deletion."īy default, variants are sorted chronologically by year of publication, to provide a historical perspective. the translocation of 137 kb from Chr5 to Chr2 by means of a circular intermediate. (2021) identified a likely causal variant, namely "a rare type of structural variation located 57 kb downstream of the HOXD1 3’UTR. ), by using a panel of 35 polycerate and 51 two-horned goats obtained from eight European populations and genotyped with the Illumina GoatSNP50 BeadChip".Īllais-Bonnet et al. (2021) "mapped the caprine POLYCERATE mutation to a 542 kb large region orthologous to that of the ovine locus (Chr2:115,143,037-115,685,115 bp on ARS1 assembly. ), we concluded that homozygosity at the goat POLYCERATE locus is an early lethal condition."Īllais-Bonnet et al. and newborn mice homozygous for a deletion including Mtx2 were never scored (binomial p = 5.7 x 10-6. (2021): "Because the knockdown of Mtx2 in zebrafish is embryonic lethal at gastrulation. (2021): "The oldest record of this condition in goat dates back from 1786, when a four-horned billy-goat was transferred from the city of Bulle in Switzerland to the model farm of French Queen MarieAntoinette in Versailles (Heitzmann 2006)"Īllais-Bonnet et al. Having more horns than the usual two, due to the early splitting of horn buds during development (A. ![]() In other species: sheep Mendelian trait/disorder:
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